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Ciphergen, Bruker, Protein Discovery, Fisher, Unleashed Informatics, Zhejiang University, GenoLogics, BSI, Genome Canada, WRI, SCBT


Ciphergen Faces Nasdaq Delisting for Low Market Cap

The Nasdaq exchange told Ciphergen Biosystems last week that it risks being delisted because its market cap has remained below $50 million for 10 consecutive business days.

Ciphergen this week said it has until June 23 to regain compliance. Its market cap currently stands at $41.4 million, according to Nasdaq.

Bruker, Protein Discovery to Co-Market Imaging Mass-Spec Products

Bruker Daltonics and Protein Discovery will co-market MALDI molecular imaging mass spectrometry products for protein biomarker discovery, the companies said this week.

Protein Discovery holds a license from Vanderbilt University to provide imaging mass spectrometry services to customers in the research, pharmaceutical, and diagnostics industries. Bruker, meantime, markets the MALDI Molecular Imager for this technique for research use only with Professor Richard Caprioli at Vanderbilt.

Protein Discovery's imaging mass spectrometry service laboratory is currently outfitted with Bruker instrumentation.

Fisher's Pierce Unit Becomes NIH's 'Preferred Vendor' for Protein Profiling

The US National Institutes of Health has chosen Fisher Biosciences' Pierce Biotechnology unit to be its 'preferred vendor' for conducting protein sample analysis, Fisher said this week.

The NIH will use Pierce's SearchLight multiplex-profiling technology to analyze secreted protein expression in samples submitted by the NIH, including the National Cancer Institute, the National Institute of Allergies and Infectious Diseases and other affiliated NIH organizations, according to Fisher.

SearchLight is a multiplex sandwich enzyme-linked immunosorbent assay in a 96-well plate-based array format. Fisher claims it can measure up to 12 secreted proteins simultaneously per well.

Financial details of the arrangement were not discussed.

Unleashed Informatics to Collaborate with Zhejiang University to Expand BIND Interaction Viewer

Unleashed Informatics and the College of Life Sciences at Zhejiang University in China will collaborate on Biomolecular Interaction Network Database software development projects, the company said last week.

The projects aim to build and expand the BIND Interaction Viewer to enable researchers to combine and represent physical and predicted molecular interactions.

The enhanced viewer will be integrated with Unleashed Informatics' BINDPlus, a subscription biomolecular database containing physical, associated, and predicted biomolecular interactions spanning genomics, proteomics, and metabolomics.

Associate Professor Chen Xin, the former manager with the BIND curation operation in Singapore, will lead the collaboration.

GenoLogics and BSI to Integrate Data-Management and -Visualization Platforms

GenoLogics Life Sciences will integrate its Proteus lab and data management solution with the PEAKS software from Bioinformatics Solutions, the two companies said last week.

BSI's PEAKS software is used for peptide sequencing and protein identification from tandem mass spectrometry data.

Proteomics researchers will be able to use PEAKS to automatically submit spectra data and Proteus will generate and manage the data for simplified collaboration and visualization.

Financial details of the deal were not disclosed.

Genome Canada Provides $16.7M to Six 'Platform' Labs

Genome Canada will provide more than CA$18.6 million ($16.7 million) to six science and technology centers over the next 15 months, funding services in DNA sequencing, genotyping, microarrays, proteomics, bioinformatics, genetic analysis, and DNA mapping, the agency said last week.

The centers, which the Canadian government calls "platforms," serve researchers funded by Genome Canada. The government said 20 percent of their activities are devoted to work related to other Canadian agencies. Two of the platforms are located in Vancouver, while Victoria, Calgary, Toronto, and Montreal host one platform each.

WRI and SCBT to Standardize Data Warehouse

Windber Research Institute and the Shanghai Center for Bioinformation Technology will jointly develop data-integration, -visualization, and -mining technologies for translational medicine research, WRI said last week.

The WRI Biomedical Informatics team, headed by Hai Hu, will work closely with the SCBIT, headed by Yixue Li.

WRI is currently involved in clinical studies and clinical trials with Walter Reed Army Medical Center in the Clinical Breast Care Program. Currently, more than 20,000 highly annotated and qualified breast disease samples with more than 500 data fields on each patient are integrated with molecular and imaging data in an Oracle-based data warehouse.


The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.