Beta Tester Says Sigma s New Top-20 Depletion Kit Improves Detection of Low-Abundance Proteins | GenomeWeb

Sigma-Aldrich's newly released ProteoPrep 20 Plasma Immunodepletion Kit depletes the 20 most abundant proteins in plasma with good specificity, and allows for the detection of more low-abundance proteins, according to a beta tester of the kit.

David Speicher, the director of the Wistar Institute's Proteomics Laboratory, who analyzed the bound and unbound fractions of plasma following ProteoPrep 20 depletion, said that only a small portion of proteins that are not targeted by the depletion kit end up in the bound fraction of plasma.

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