It’s that time of year again: Next week, the Gaylord Opryland Hotel in Nashville, Tenn., will play host to the 52nd annual American Society for Mass Spectrometery Conference.
The biggest mass spec event of the year, which runs from May 23 to 27, will offer plenty for the proteomics scientist: Not only will the major vendors be displaying new launches in the exhibit hall, which will be opened each night until 8 p.m., but the conference will also be filled with hundreds of presentations and posters relating to proteomics from academics and vendors alike (see tables p. 4-8). Below are new releases and applications to look for from the major vendors.
Agilent will use ASMS to showcase the ChipLC-MS system that it first introduced at Pittcon in March (see PM 3-12-04). Agilent said it hopes the system will eventually replace traditional nano-LC columns. The company also will show a new, integrated LC-MS/software system with low flow rates targeted for proteomics applications (see p. 2). In addition, Agilent will present posters describing a grouping algorithm called Sheepshank for deconvoluting ion trap and Q-TOF spectra, an in-line gel filtration system for preparing samples of protein-ligand complexes for MS analysis, and a new AP-MALDI source.
ABI will focus much of its exhibition space on displaying applications of its 4000 Q-TRAP system, and will present several lectures and posters detailing uses of the isobaric, multiplexed ICAT reagents, called iTRAQ, that it first informally introduced in February (see PM 3-5-04) and formally launched this week. In conjunction with iTRAQ, ABI is releasing ProQUANT software for analysis of experiments using iTRAQ. The company will also put on display the first version of its long-awaited MALDI molecular imaging system, developed in collaboration with MDS Sciex and Richard Caprioli at Vanderbilt University (see PM 7-1-02, 12-5-03). This version will use new MALDI imaging software and a fast high-repetition laser in conjunction with ABI’s Q-STAR XL Hybrid LC-MS/MS system to image drugs and metabolites in tissue.
Bruker has kept mum on what it might release at ASMS, but listings of poster abstracts show that the company will be presenting a new software tool called ScoreBooster that is intended for improving and automating internal calibration in peptide mass fingerprinting experiments. It will be discussing an SPR-MS interface developed in collaboration with Biacore, which uses its ClinProt magnetic beads and AnchorChip products to combine protein interaction analysis with mass spec-based identification. Bruker will also present results from an ovarian cancer biomarker study, using ClinProt, conducted in collaboration with Harvard Medical School.
Ciphergen has kept similarly quiet about any new instruments that it might release, but the company will present a poster on a new SELDI chip that uses polyurethane chemistry.
Thermo Electron/Amersham Biosciences (GE Healthcare)
Thermo has announced it will comment during a press conference at ASMS on the status of its relationship with GE Healthcare now that longtime proteomics partner Amersham is officially part of GE. For now, all signs indicate that this relationship with the former Amersham is going strong. The companies will jointly present posters on DeCyder for mass spectrometry, a new version of Amersham’s gel analysis software for LC-MS data. The software integrates visualization, detection, statistics, and comparison tools for relative quantification, according to the companies. Amersham will also show a poster describing a new bioinert MDLC system for phosphopeptide analysis.
Thermo has said that it will present further updates to its LTQ-FT machine at ASMS (see PM 2-27-04), and it will present several posters describing applications of the instrument.
In addition to presenting its new Q-TOF and Q-TOF-UPLC (see PM 4-30-04) for proteomics applications, Waters will also introduce a new MALDI system targeted toward proteomics and biomarker applications, according to Waters spokesman Brian Murphy. In addition, the company is presenting a slew of posters and lectures featuring new products or applications, including: a direct-flow nanoLC-MS system; an alternative to Data Dependant Analysis LC-MS/MS called qualitative ion mapping, which the company says produces better reproducibility in protein identification of complex mixtures; a new MALDI MS/MS method for sequencing phosphopeptides using two different reflectron voltages; and a mapping algorithm for analysis of peptides by accurate mass measurements (see tables).