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Applied Biosystems, Agilent Technologies

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Applied Biosystems this week announced that iTRAQ, its new isobaric, multiplexed, stable isotope tags that it first informally introduced at the Association of Biomolecular Research Facilities meeting in Portland in February (see PM 3-5-04, see also story p. 1), is now commercially available and will be formally launched at the American Society for Mass Spectrometry meeting next week. The new reagents differ from traditional ICAT reagents in that they can label all peptides rather than being limited to peptides that contain cysteine, the company said. In addition, they can be used in multiplexed experiments up to 4-plex. The reagents are compatible with the company’s Q-STAR and Q-TRAP mass specs, and will become available on its 4700 Proteomics Analyzer this summer.

Along with the new reagents, the company is launching Pro QUANT software for analysis of data from LC-MS experiments using the reagents. The software provides automatic data processing and links protein information with the Celera Discovery System database and the Panther protein database.


Agilent Technologies this week launched an integrated LC-MS system for protein identification based on its Agilent 1100 Series LC platform, and available with its 1100 Series XCT Plus ion traps or its 1100 Series XCT ion trap. The system is targeted toward proteomics applications, particularly for the “nonexpert user.” It will include columns, mass specs, software, and a manual of protocols for the workflow. Agilent’s Spectrum Mill software will be offered as an optional component of the system.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.