Analyses Find DIA Mass Spec Approaching, Surpassing Shotgun Methods for Protein Identification | GenomeWeb

NEW YORK (GenomeWeb News) – With a new crop of instruments and methods hitting the market some analyses show data-independent acquisition mass spec approaching, or even surpassing, traditional data-dependent workflows.

In an interview with ProteoMonitor last November, Swiss Federal Institute of Technology Zurich researcher Ruedi Aebersold noted that while DDA methods typically identified more total peptides, when measuring several replicates DIA methods generate "a higher number of consistently identified peptides."

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