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Agilent Technologies, Millipore, AnaSpec, Tripos

Agilent Technologies last week launched its EZChrom Elite 3.2 software for use with HPLC data. In addition to compatibility with Agilent’s 1200 Series liquid chromatographers, the software works with all makes of LCs, an Agilent spokesman said.
The 3.2 version features a new navigation pane for easy access to software functions and analysis tools that allow users to specify custom identifiers and analysis parameters on a peak-by-peak or injection basis directly in the sequence table, the company said.

Millipore launched this week the first round of adenoviral shRNA expression vector reagents targeting the human druggable genome. The classes included in this release represent all the major protein classes amenable to small-molecule intervention, the company said in a statement. That includes kinases, GPCRs, and secreted proteins.
The AdenoSilence vectors are available in three different sequence variants sold separately or as a kit. The vectors “allow for single-step delivery of shRNA through the direct application of the virus supernatants onto a primary cell culture, thereby making any additional transfection reagents or complex transfection protocols unnecessary,” Millipore said.

AnaSpec released three protein phosphatase assay kits this week. The fluorimetric EnzoLyte FDP assay kit is optimized for assaying protein phosphatases requiring a pH of at least 6.5 for optimal activity, the company said in a statement. Its EnzoLyte MFP assay kit, also a fluorimetric assay, is for phosphatases that require a pH of no more than 6.5. AnaSpec’s colorimetric kit, the EnzoLyte pNPP assay kit, utilizes p-nitrophenyl phosphate as a substrate and shows high sensitivity and a wide linear range. The detection limit is generally 3 ng or lower.

Tripos this week launched the Advanced Protein Modeling software package combining homolog identification, sequence alignment, and interactive comparative protein structure modeling. APM is available as an optional component of Tripos’ SYBYL 7.3 product line and is based on the FUGUE and ORCHESTRAR technologies.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.