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Affibody, InforSense, BSI Proteomics, Michael Barber Centre for Mass Spectrometry

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Affibody of Stockholm and InforSense of London have released KDE GeneSense, a program for interpreting experimental genomics, transcriptomics, and proteomics data with available scientific knowledge. GeneSense couples Infor- Sense’s Kensington Discovery Edition (KDE) informatics environment with Affibody’s data management, biological annotation, and visual representation technology.

 

BSI Proteomics of Gaithersburg, Md., has launched ARD FivePack, a protein crystalllization system that is based on BSI’s Automated Robotic Dynamic Crystalization System, which can crystallize proteins in 100 different chambers at 100 different conditions simultaneously using 2 ml of protein in each chamber. The ARD FivePack allows to set up five different proteins for crystallization and can be set up in less than one hour, according to the company.

 

The PBIL Lyon-Gerland in France has made available SuMo, a system for extracting structural and possibly functional similarities in three-dimensional structures of proteins, though a web interface at http://sumo-pbil.ibcp.fr. The interface allows users to screen a database of 11,500 ligand binding sites with a given protein structure or substructure, and to screen the PDB with a given ligand binding site. SuMo is based on a description of three-dimensional structures of macromolecules using various types of chemical groups with specific geometry, symmetry, and parameters.

 

The Michael Barber Centre for Mass Spectrometry is holding a course,“Mass Spectrometry for Protein & Peptide scientists” at the University of Manchester Institute for Science and Technology from June 30th -July 3rd. The course, sponsored by Waters, will provide a practical introduction to the analysis of proteins by mass spectrometry. For more information, see www.ch.umist.ac.uk/cms/courses/courses.html or www.micromass.co.uk/umist.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.