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ActiveSight, Thermo Electron

ActiveSight lauched this week its inducible nitric oxide synthase, oriNOS, and peroxisome proliferators-activated recptor gamma, or PPAR gamma, “ready to go” protein crystals for drug discovery. The company now has 14 proteins in its portfolio.
iNOS  produces large bursts of nitric oxide as part of the immune response. Overproduction of it has been linked to inflammation and autoimmune diseases, ActiveSight said.
PPAR is the target of the glitazone family of drugs and in addition to being a diabetes target, may also play a role in cancer and inflammation. 

Thermo Electron has updated its Darwin LIMS for pharmaceutical manufacturing R&D and QA-QC. Darwin 1.1 now features extensive interfacing capabilities, providing tight integration with SAP, and historical data trending and charting functionality.
“The embedded charting and trending for product stability testing allows for real- time data review and rapid reporting,” the company said in a statement. Darwin 1.1 is also optimized now to operate on the Oracle 10g platform.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.