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NEW YORK (GenomeWeb) – A team led by researchers at Yale University has used data independent acquisition mass spectrometry (DIA-MS) combined with CRISPR gene deletion to study the function of a protein linked to Down Syndrome and tumor immunity.

Described in a study published this month in Proteomics, the effort looked at the proteomic effects of knockout of the non‐histone chromosomal protein HMG‐14 (HMGN1), which is known to play a role in regulating chromatin structure.

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