NEW YORK (GenomeWeb) – Using a combined genomic-proteomic approach, Stanford University researchers have identified a group of neoantigen peptides in human mantle-cell lymphoma (MCL).

Published this week in Nature, the study looked at tumor neoantigen peptides presented by the major histocompatibility complex (MHC) class I and class II molecules in 17 patients and found that all the neoantigen peptides they discovered came from the immunoglobulin variable regions and, with one exception, were presented by MHC class II molecules.

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