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Recent Patents of Interest in Proteomics: Jun 11, 2010

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US Patent 7,735,146. Protein microscope. Inventors: Akos Vertes, Mark E. Reeves, Fatah Kashanchi. Assignee: George Washington University

Covers a system and method that combines modified MALDI mass spectrometry and scanning near-field optical microscopy devices and techniques to analyze samples containing molecules of interest. The invention is "directed to an instrument for identifying peptides, proteins, and other biomolecules within a tissue or cell and providing information on their spatial and temporal distribution," according to the description.


US Patent 7,729,868. Method for analyzing structure of glycoprotein. Inventors: Koichi Tanaka, Yoshinao Wada, Yuzo Yamazaki, Yuko Fukuyama. Assignee: Shimadzu; Osaka Prefectural Hospital Organization

The method offers a simplified way of analyzing the structure of glycoproteins, using mass spectrometry to analyze them in their native forms without the need for separating the sugar chains.


US Patent 7,723,917. Method of de novo sequencing of peptide using the MALDI mass spectrometry, method and apparatus for preparing sample for MALDI mass spectrometry. Inventors: Seung-Koo Shin, Kyung-Hwan Jeong, Hye-Joo Yoon, Min-Soo Suh, Jong-Cheol Seo. Assignee: Postech Foundation; Posco; Postech Academy-Industry Foundation

Covers a method for improving the detection sensitivity of target peptides and the uniformity of detection of various daughter ions by chemically modifying sample peptides via guanidination and/or esterification prior to analysis with MALDI tandem mass spectrometry. The method will enable "perfect de novo sequencing with tandem mass spectrometry only, without database search," according to the abstract.


US Patent 7,723,125. Highly sensitive proteomic analysis methods, and kits and systems for practicing the same. Inventors: Grigoriy S. Tchaga. Assignee: Clontech Laboratories

Covers methods of determining whether a sample contains one or more analytes – particularly proteins – by using an array of binding agents containing an epitope binding domain of an antibody and subsequently detecting the presence of the binding complexes on the array. Included are "kits, systems and other compositions of matter" for employing the methods.


US Patent 7,714,280. Time-of-flight secondary ion mass spectrometer. Inventors: Manabu Komatsu, Hiroyuki Hashimoto. Assignee: Canon

Covers a time-of-flight mass spectrometer that measures a mass spectrum of secondary ions generated from a sample. The instrument can "perform imaging detection efficiently [for] compositions which construct a sample, and in particular, organic substances such as protein and peptide," according to the description.


US Patent 7,714,276. Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry. Inventors: Paul Pevsner, Frederick Naftolin, Douglas C. Miller, Dean Hillman, Brian K. Stall, Steven M. Wishnie. Assignee: New York University

The invention relates to using post source decay or collision induced dissociation direct tissue MALDI-TOF or MALDI-TOF-TOF mass spectrometry combined with bioinformatics to identify biological molecules in a tissue or cellular sample without the need for further protein extraction.


US Patent 7,713,525. Biomarkers for cancer sensitivity and uses thereof. Inventors: Robert P. Kimberly, Tong Zhou, Takeshi Isoyama. Assignee: The UAB Research Foundation

Covers the use of fructose-bisphosphate aldolase A, phosphoglycerate kinase 1, peroxiredoxin 1, cofilin 1, and histone H4 as biomarkers for evaluating anti-cancer efficacy and sensitivity.

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