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NIGMS Plans New PSI Grants

NEW YORK (GenomeWeb News) – As part of the Protein Structure Initiative, the National Institute of General Medical Sciences will fund research into new technologies or methods for studying proteins, high-throughput structure determination of certain proteins, structural genomics, and other potentially related structural biology studies.

NIGMS will give five-year grants of various amounts to research that will focus on technologies and methods for overcoming "major bottlenecks of high-throughput structural biology" with an emphasis on "challenging proteins that are not currently amenable to high-throughput methods," according to a National Institutes of Health request for applications.

NIGMS wants researchers to propose studies that could have "a major impact" on improving high-throughput structure determination, and to develop tools that could have wide applicability and would be "portable and scalable."

Scientists also are encouraged to form multidisciplinary research teams from different institutions and from different scientific fields, and they should plan to release data from the studies rapidly.

These studies may focus on developing innovative methods for membrane protein production, crystallization, and structure determination. They also could aim to expand knowledge of cDNA libraries, ligands and cofactors, post-translational modification, or binding partners of proteins from humans and other higher eukaryotes. Scientists also may seek to study the expression, solubility, and crystallization of proteins that are different when an interacting protein is not present.

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