MALDI-Based Fatty Acid Profiling Offers Infectious Disease Dx Potential | GenomeWeb

PALM SPRINGS, CALIFORNIA (GenomeWeb) – Scientists from the Colorado School of Mines have developed a method to identify bacteria at the strain level using MALDI-TOF mass spectrometry to characterize fatty acids from the phospholipid cell membrane.

Kent Voorhees and Chris Cox presented on their method this week at the 2016 Mass Spectrometry: Applications to the Clinical Lab conference. Dubbed metal oxide laser ionization (MOLI) mass spec, they demonstrated an ability to distinguish bacterial species at a taxonomic level that mass spec-based protein profiling often struggles with.

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