NEW YORK (GenomeWeb) – With efforts to integrate proteomics and genomics gaining steam, a number of recent proteogenomic studies have sought to leverage this combination to delve deeper into samples in search of protein-level evidence for features like splice variants.

Solid evidence exists that alternative splicing of messenger RNA can lead to the expression a variety of different RNA transcripts from a single gene. Determining whether these transcripts are translated into stable proteins, however, has been a more challenging task.

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