Researchers used a screen of mutation hotspots present in kinase active domains to identify protein kinases commonly inactivated by cancer-linked mutations.
The study used analysis of intact proteins to identify mutation-linked post-translational modifications involved in KRAS activation and membrane attachment.
While mass spec-based single-cell proteomics is still in its infancy, recently developed methods allow the ID of thousands of proteins at the single-cell level.
In a poster at this week's AACR annual meeting, researchers used the firm's tech to investigate how the addition of a cytokine agonist can improve CAR-T treatment.
With a series of recent collaborations in hand, the company is leveraging its experience in autoimmune biomarkers to move into the immunoncology space.
