Named shieldin, the complex is involved in DNA damage repair processes and also plays a role in sensitizing BRCA1-depleted tumor cells to PARP inhibitors.
Freenome will leverage proteomics firm Biognosys' technology to add protein quantification to the development of Freenome's first commercially available screening test.
Organic revenues were up 2 percent, as the company saw solid demand among its pharma customers but a decline in sales of its mass spectrometry instruments.
Researchers used a screen of mutation hotspots present in kinase active domains to identify protein kinases commonly inactivated by cancer-linked mutations.
The study used analysis of intact proteins to identify mutation-linked post-translational modifications involved in KRAS activation and membrane attachment.
In PNAS this week: a genomic, transcriptomic, and metabolomic analysis of the tea plant, Arabidopsis thaliana's adaptations to specific local environments, and more.
