Skip to main content
Premium Trial:

Request an Annual Quote

TriLink to Sell QuantiBact TINA Oligos Under Licensing Pact


TriLink Biotechnologies said today that it has inked a licensing agreement with Denmark's QuantiBact to offer twisted intercalating nucleic acid, or TINA, modified oligonucleotides.

TINA molecules are intercalators placed at the 5' end of primers to stabilize duplex formation, thus improving the sensitivity and specificity of endpoint and real-time PCR, TriLink said. The molecules may be used wherever an enhanced melting temperature is required such as triplex formation, or potentially even gene silencing, the company said.

QuantiBact scientists published a paper last year in PLoS One describing how adding ortho-TINA molecules at the 5' position to standard primers in a qPCR experiment enabled 100 percent efficiency in "significantly stressed reaction conditions," including lower primer concentrations and increased annealing temperatures (PCR Insider, 6/21/2012).

TriLink said it will make the modified oligos available in June.

"At TriLink we pride ourselves on our quality and our ability to handle unique nucleic acid modifications," TriLink President and CEO Richard Hogrefe said in a statement. "This makes us an ideal manufacturer of TINA oligos."

The Scan

Close Panel Vote on Califf Nomination

The New York Times reports there was a close committee vote to advance the nomination of Robert Califf to lead the US Food and Drug Administration to the full Senate.

Task Force Reports on Scientific Integrity

Nature News writes that that a new task force report recommends that the US establish a cross-agency scientific integrity council.

Across the Hall

Genetic testing, closed-circuit cameras, and more show how a traveler, without any contact, infected others at a New Zealand quarantine facility, CNN reports.

Science Paper Examines Influence of Chromatin Modifications on Obsessive-Compulsive Disorder

In Science this week: genes regulating chromatin modification may contribute to OCD risk.