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Product Watch: Covaris; Roche and Hamilton; and Mo Bio Laboratories

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Covaris last week introduced a single-tube FFPE DNA extraction kit for high-yield, large molecular weight DNA extraction from formalin-fixed, paraffin-embedded tissue samples.

The new product uses adaptive focused acoustic technology to emulsify and separate paraffin while simultaneously rehydrating the tissue sample in an aqueous solution in a few minutes. Covaris focused ultrasonicators enable purely mechanical processing of the samples, eliminating the need for organic solvents.

AFA technology is the standard method for DNA fragmentation for next-generation sequencing, Covaris said. An optional DNA fragmentation step can be included in the workflow to precisely size the DNA for applications requiring short fragments, such as NGS. This optional integrated single-tube DNA shearing streamlines sample preparation while doubling total DNA yield when compared to extraction without fragmentation, Covaris said.


Roche and Hamilton Robotics this week introduced an integrated platform enabling automated DNA sample enrichment for Roche's 454 GS Junior sequencer

The platform integrates Roche's REM e system with Hamilton's Microlab Nimbus NGS workstation, thus reducing hands-on time, minimizing operational variability, and providing more consistent results.

The platform has also been tested and validated to automate the emulsion PCR breaking, bead enrichment, and sequence primer annealing steps in the GS Junior sample prep workflow, the companies said.


Mo Bio Laboratories this week launched the PowerMag Seed and PowerPlant Pro-htp 96-Well DNA isolation kits for high-throughput purification of nucleic acids from seeds and plants.

The PowerMag Seed DNA isolation kit is the latest in Mo Bio's PowerMae line of kits for hands-free nucleic acid isolation using magnetic beads. The PowerPlant Pro-htp 96 Well DNA kit is a high-throughput version of the company's PowerPlant Pro DNA Isolation Kit for isolating high-quality DNA using silica spin filter technology.

Both kits feature bead-based lysis for uniform representation of the nucleic acid population; inhibitor removal technology for complete removal of PCR inhibitors commonly found in plants and seeds (for example, polysaccharides and polyphenolics) to eliminate false negatives in downstream applications such as qPCR; and phenolic separation solution, which breaks the bond between DNA and polyphenolics, increasing DNA yield in highly phenolic samples.

The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.