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Product Watch: Oct 6, 2011

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Bio-Rad this week introduced its Precision Melt Supermix for high-resolution-melt-based detection of SNPs and CpG methylation for epigenetic studies.

The new reagents include EvaGreen dye, which is required for detection of class III/IV SNPs, Bio-Rad said. The supermix discriminates all four SNP classes across a broad range of amplicons, allowing the study of any genomic region, regardless of amplicon length and GC content.

The supermix is also fully compatible with bisulfite-converted DNA and allows for accurate detection of CpG methylation status, Bio-Rad said. In addition, its room temperature stability allows researchers to screen thousands of samples using Bio-Rad’s CFX96 Touch or CFX384 Touch real-time PCR systems, but the reagents are compatible with all HRM-capable thermal cyclers.


DuPont Qualicon this week introduced the BAX System STEC Suite, a trio of real-time PCR assays that enable food processors, reference labs, and government labs to detect Shiga toxin-producing Escherichia coli, or STEC, most commonly associated with severe foodborne illness.

The BAX System assay detects a combination of virulence genes called stx and eae to quickly and cost-effectively clear negative samples in production lines, DuPont said. Two multiplex PCR panels can determine which of the top six non-O157 STEC serogroups — O26, O45, O103, O111, O121, and O145 — are present in positive samples.

DuPont Qualicon said that it developed the tests in collaboration with the Agricultural Research Service of the US Department of Agriculture.

The Scan

Close Panel Vote on Califf Nomination

The New York Times reports there was a close committee vote to advance the nomination of Robert Califf to lead the US Food and Drug Administration to the full Senate.

Task Force Reports on Scientific Integrity

Nature News writes that that a new task force report recommends that the US establish a cross-agency scientific integrity council.

Across the Hall

Genetic testing, closed-circuit cameras, and more show how a traveler, without any contact, infected others at a New Zealand quarantine facility, CNN reports.

Science Paper Examines Influence of Chromatin Modifications on Obsessive-Compulsive Disorder

In Science this week: genes regulating chromatin modification may contribute to OCD risk.