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Product Watch: Jul 14, 2011


Illumina this week announced the availability of its new TruSeq custom enrichment kits for designing and targeting genomic regions of interest ranging from 700 kilobases to 15 megabases of cumulative DNA.

The TruSeq Custom Enrichment kits use the same underlying assay design as the company's TruSeq Exome Enrichment kits and provide researchers with additional experimental design flexibility, Illumina said. The new kits' targeted sample capture protocols are also fully compatible with Illumina's TruSeq DNA sample preparation kits.

Other features include multiplexed sample enrichment of up to 12 samples; high coverage uniformity and enrichment rates with an input requirement of 1 µg of DNA; easy-to-use master-mixed formulations and plate-based processing for up to 96 samples; and internal quality controls for each assay step from library prep through enrichment.

Illumina said it is also releasing an introductory version of DesignStudio, a flexible online tool that enables the rapid design of custom probes for multiple applications.

Bio-Rad this month launched the C1000 Touch thermal cycler, a color touch-screen version of the company's C1000 thermal cycler.

The new touch-screen navigation feature allows researchers to edit, run, and save protocols more easily. The instrument's Protocol Autowriter software, which creates a protocol in three steps, is accessible from the home screen of the C1000 Touch.

Bio-Rad said that it also developed a new 96-well block for the instrument that can hold 0.2- or 0.5-mL tubes for reaction volumes between 50 µL and 125 µL. The large reaction volume is useful for sample preparation upstream of applications such as next-generation sequencing using emulsion PCR and microarray library amplification, Bio-Rad said.

Capital Biosciences is now offering a service for detecting alternative lengthening of telomeres in tumor tissues and cell lines.

The assay is based on the discovery of so-called C-circle telomeric DNA associated with ALT in cancer cells with negative telomerase activity, Capital Biosciences said. Normal cells and tumors with highly active telomerase do not have detectable C-circles.

The ALT detection method involves rolling circle amplification detection of linear single-stranded DNA by hybridization with a specific 32P-labeled probe. The company said that it is also developing non-radioactive methods for ALT detection.

Filed under

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.