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Product Watch: Dec 16, 2010


Agilent Technologies said this week that its SureSelect Target Enrichment System now supports Roche-454 Life Sciences' next-generation sequencing platform.

The SureSelect system enables users to sequence only genomic regions of interest rather than entire genomes, and allows enrichment of targets ranging from smaller than 200 kb to more than 50 Mb in a single tube. The system also enables target enrichment of user-specified regions, the human kinome, the human X chromosome, and the human exome, Agilent said.

Agilent's SureSelect also supports the Illumina Genome Analyzer, Life Technologies' SOLiD 4, and HiSeq sequencing platforms.

Agilent also said this week that Gaithersburg, Md.-based EdgeBio has been appointed as a Certified Service Provider for SureSelect. Agilent said EdgeBio's SureSelect CSP status is specifically applicable to Life Technologies' SOLiD 4 system.

TriLink Biotechnologies this week launched CleanAmp 7-deaza-dGTP, a hot start solution for PCR amplification of problematic GC-rich sequences.

When DNA targets high in GC content are amplified, PCR product formation can often be compromised by inadequate strand separation and the propensity for complex secondary structure formation, TriLink said.

CleanAmp 7-deaza-dGTP is a fusion of the secondary structure-reducing nucleotide analog 7-deaza-dGTP and TriLink's CleanAmp dNTP Hot Start technology. The product is available individually for amplification of routine GC-rich targets or as the CleanAmp 7-deaza-dGTP Mix, which is recommended for more challenging targets with higher GC content, TriLink said.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.