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New England Biolabs Uses Rubicon's Single-Cell Amplification Tech in New WGA Kit


New England Biolabs said this week that it has licensed single-cell amplification technology from Rubicon Genomics that it will market in a new kit for whole-genome amplification of single cells and low quantities of DNA.

The Single Cell Whole Genome Amplification kit is NEB's first product for the single-cell amplification market. The company said it expects the new kit to find use in "numerous research applications, including cancer studies."

Jim Koziarz, President and CEO of Rubicon, said in a statement that the company's single-cell amplification technology "has already been widely adopted in the in vitro fertilization market, and we are excited at the prospects this product has in research applications."

According to NEB, the Single Cell WGA kit can amplify total DNA from single cells or their DNA equivalent about 1 million-fold to produce 2 mg to 5 mg of amplified DNA in under three hours. It can also be used in situations "where the low input amount is uncertain as it works well over a range of inputs up to thousands of cells or several [nanograms of] DNA to achieve this final yield of amplified DNA."

The company said that the kit has been used successfully for single blastomeres, polar bodies, trophoblasts, amniocytes, and cultured cells and achieves a 95 percent amplification success rate.

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