Clinical researchers from Johns Hopkins University School of Medicine have developed a technique called tandem duplication, or TD-PCR, for detecting internal tandem duplications of the FLT3 gene, which has been associated with a poor prognosis in acute myeloid leukemia patients

According to the researchers, the assay has a high degree of sensitivity and specificity, with a limit of detection approaching just a single mutant molecule, and as such may prove useful as a tool to monitor minimal residual disease in AML patients.

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