Thermo Fisher Scientific has been awarded US Patent No. 8,378,115, "Monomethine dyes."
Charles Brush, Jianqin Liu, Peter Czerney, and Matthias Wenzel are named as inventors.
Describes monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single-stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR.
Protisvalor Mediterranee has been awarded US Patent No. 8,378,078, "Diagnosis of Whipple's disease."