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IP Watch: Samsung, BioMerieux, Bio-Rad, Abbott, Micronics, Argos, BD, and Gen-Probe Win US Patents

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Samsung Electronics has been awarded US Patent No. 8,222,391, "Oligonucleotide primer set for amplifying target sequence(s) of norovirus; oligonucleotide probe or probe set specifically hybridizing with target sequence(s) of norovirus; microarray immobilized with the probe or probe set; and method of detecting norovirus using the probe or probe set."

Ji-young Oh and Sook-young Kim are named as inventors on the patent.

Provides an oligonucleotide primer set for amplifying at least one target sequence of the genomic RNA of norovirus; an oligonucleotide probe or probe set specifically hybridizing with at least one target sequence of the genomic RNA of norovirus; a microarray immobilized with the probe or probe set; and a method of detecting norovirus using the probe or probe set.


BioMérieux has been awarded US Patent No. 8,222,389, "Method for lowering both sequence variations and increase of baseline effects in a diagnostic hybridization assay, assay for performing such a method, and probe for use in the assay."

Fokke Venema is named as inventor on the patent.

Relates to the use in a diagnostic hybridization assay of a molecular beacon probe for lowering the effect of sequence variations in a nucleic acid analyte and/or the IBL effect due to the possible opening of the stem-loop structure of a molecular beacon by way of enzymes contaminating the amplification. The assay comprises the steps of contacting a set of primers with a sample containing the nucleic acid analyte to amplify the analyte; and detecting the amplified analyte or its complement using a molecular beacon probe that comprises one or more nucleotides and/or nucleotide analogues that have an affinity-increasing modification. The invention also relates to such molecular beacon probes and to a kit for performing a diagnostic assay using said probes.


Bio-Rad has been awarded US Patent No. 8,222,382, "HIV type and subtype detection."

Marie-Philippe Biron and Alain Horvais are named as inventors on the patent.

The patent relates to the detection of HIV by amplification and PCR-based methods, according to its abstract.


Abbott Laboratories has been awarded US Patent No. 8,222,048, "Automated analyzer for clinical laboratory."

Patrick Fritchie, Gregory Gardner, and Richard Mahoney are named as inventors on the patent.

Describes a laboratory automation system capable of carrying out clinical chemistry assays, immunoassays, nucleic acid amplification assays, and any combination thereof, employing one or more microwell or deep multiwell plates as reaction vessels. The use of microwell plates as reaction vessels enables the laboratory automation system to assume a variety of arrangements, i.e., the laboratory automation system can comprise a variety of functional modules that can be arranged in various ways. In order to effectively carry out immunoassays by means of microwell plates, a technique known as inverse magnetic particle processing can be used to transfer the products of immunoassays from one microwell of a microwell plate to another.


Micronics (Sony) has been awarded US Patent No. 8,222,023, "Integrated nucleic acid assays."

Frederick Battrell, John Gerdes, John Williford, Denise Hoekstra, Wayne Breidford, Stephen Mordue, John Clemmens, Melud Nabavi, and Mark Kokoris are named as inventors on the patent.

Discloses integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples. The devices are single-entry, sanitary, and disposable, and enable simplex or multiplex nucleic acid target detection, i.e., assay panels for multiple infectious agents, or assay panels for cancerous cell types. The patent also discloses methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus.


Argos Therapeutics has been awarded US Patent No. 8,221,981, "Primers and probes for the amplification and detection of HIV Gag, Rev, and Nef polynucleotides."

Irina Tcherepanova, Aijing Starr, and Brad Lackford are named as inventors on the patent.

Relates to improved methods and compositions for the nucleic acid amplification of one or multiple variants of human immunodeficiency virus present in a sample, preferably from a pathogen-infected individual. In particular, the patent provides novel primers, methods, and kits for the amplification of one or more species of HIV rev, gag and nef nucleic acids. The amplified HIV nucleic acid can be used to identify and/or quantitate HIV variants present in a sample. Nucleic acids or the proteins encoded thereby can also be used directly as vaccines or to transfect/load antigen-presenting cells. The loaded antigen-presenting cells can be used as a vaccine for the treatment or prevention of HIV infection.


Becton Dickinson has been awarded US Patent No. 8,221,976, "Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification."

Relates to a method of detecting the presence or absence of herpes simplex virus in a sample based on amplifying a portion of the glycoprotein G gene of HSV and detecting the presence of the amplified nucleic acid using certain primers and detector primers. The method further identifies the type of HSV, either HSV-1 or HSV-2, in a sample. The patent also describes a kit comprising the primers and detector primers, and which may be used with the described amplification method.


Gen-Probe has been awarded US Patent No. 8,221,682, "System for incubating the contents of a reaction receptacle."

Kelly Ammann, Robert Schneider, and Robert Smith are named as inventors on the patent.

Describes an automated analyzer for performing multiple diagnostic assays. The analyzer includes multiple modules in which aspects of the assay are performed on fluid samples contained in reaction receptacles, including stations for automatically preparing a sample, pre-heating the sample, incubating the sample, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. A receptacle transporting system moves reaction receptacles from one station to the next. The patent also describes a method for performing an assay that includes an automated process for isolating and amplifying a target analyte. The process is performed by moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for pre-heating and incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the analyte after the separation step and before incubation.

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