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IP Watch: Roche, Hologic, Cornell, USC, Others Win US Patents

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Cornell Research Foundation has been awarded US Patent No. 8,642,269, "Detection of nucleic acid sequence differences using coupled polymerase chain reactions."

Francis Barany, Matthew Lubin, George Barany, Robert Hammer, and Phillip Belgrader are named as inventors.


Roche Diagnostics has been awarded US Patent No. 8,642,266, "Single cell mRNA quantification with real-time RT-PCR."

Martin Bergtsson, Michael Kubista, Anders Stahlberg, and Linda Stroembom are named as inventors.


Roche Molecular Systems has been awarded US Patent No. 8,642,293, "Disposable device for analyzing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus."

Emad Sarofim, Olivier Elsenhans, Martin Kopp, and Hans-Peter Wahl are named as inventors.


Zoragen Biotechnologies has been awarded US Patent No. 8,642,264, "Method of quantifying target and reference nucleic acid."

Nora Szasz is named as the inventor.


University of Southern California has been awarded US Patent No. 8,642,263, "Highthroughput methods comprising analysis of repetitive element DNA methylation."

Peter Laird, Daniel Weisenberger, Mihaela Campan, and Tifany Long are named as inventors.


Erasmus University Medical Center has been awarded US Patent No. 8,642,295, "Circular chromosome conformation capture (4C)."

Wouter De Laat and Frank Grosveld are named as inventors.


Gen-Probe (Hologic) has been awarded US Patent No. 8,642,268, "Methods and compositions for nucleic acid amplification."

Steven Brentano, Dmitry Lyakhov, James Carlson, Norman Nelson, Lyle Arnold Jr., and Michael Becker are named as inventors.


The US Army has been awarded US Patent No. 8,642,746, "Unique calibrator polynucleotides and methods of using in quantitative nucleic acid assays."

Christopher Phillips, Albert Ruff, and James Dillman III are named as inventors.


Washington University has been awarded US Patent No. 8,642,279, "Method for predicting risk of metastasis."

William Harbour is named as the inventor.


The Children's Hospital of Philadelphia has been awarded US Patent No. 8,642,265, "Compositions and methods for the detection of topoisomerase II complexes with DNA."

Carolyn Felix and Donald Baldwin are named as inventors.


Trovagene has been awarded US Patent No. 8,642,261, "Genetic marker for detection of human papillomavirus."

Hovsep Melkonyan, Samuil Umansky, and Zhenghan Xin are named as inventors.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.