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IP Watch: Roche, Gen-Probe, Seegene, Corbett, PSU, Quanta Biosciences, APDS Win US Patents

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Corbett Life Science has been awarded US Patent No. 8,124,413, "Thermocycler and sample port."

Keith Stanley and John Corbett are named as inventors on the patent.

Relates to continuous flow systems, in particular thermocyclers, for the automated and continuous cycling of fluid between a plurality of temperature zones to amplify nucleic acids. The invention also relates to an improved sample port for introducing a volume of a liquid sample into a continuous flow system.


Seegene has been awarded US Patent No. 8,124,346, "Annealing control primer and its uses."

Jong-Yoon Chun is named as inventor on the patent.

Relates to an annealing control primer for improving annealing specificity in nucleic acid amplification, and its applications to all fields of nucleic acid amplification-involved technology. The primer comprises (a) a 3'-end portion having a hybridizing nucleotide sequence substantially complementary to a site on a template nucleic acid to hybridize therewith; (b) a 5'-end portion having a pre-selected arbitrary nucleotide sequence; and (c) a regulator portion positioned between said 3'-end portion and said 5'-end portion comprising at least one universal base or non-discriminatory base analog, whereby said regulator portion is capable of regulating an annealing portion of said primer in association with annealing temperature.


The Penn State Research Foundation has been awarded US Patent No. 8,124,342, "Methods for nucleic acid manipulation."

Stephen Benkovic and Frank Salinas are named as inventors on the patent.

Describes a method for replicating and amplifying a target nucleic acid sequence. A method of the invention involves forming a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high-fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein, and a clamp loader protein derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.


Quanta Biosciences has been awarded US Patent No. 8,124,340, "Methods for enrichment of selected RNA molecules."

Ayoub Rashtchian is named as inventor on the patent.

Provides improved methods of studying RNA molecules. In particular, provides methods of treating mixtures of RNA molecules so as to enrich the mixture for a desired type of RNA molecule. For example, the methods permit depletion of mRNA from complex mixtures to facilitate study of microRNAs in the mixture.


Roche has been awarded US Patent No. 8,124,338, "Use of TDE for isolation of nucleic acids."

Horst Donner, Frank Bergmann, Nina Lassonczyk, Manfred Watzele, and Marcus Schmid are named as inventors on the patent.

Describes the use of tetraethylene glycol dimethyl ether for adsorbing nucleic acids to solid phases such as those with silica surfaces. To this end, the invention also provides compositions comprising TDE. The patent also discloses methods and kits to purify nucleic acids from samples. Particularly, the invention encompasses methods for purifying nucleic acids with low molecular weight. The purified nucleic acids are suited for assays to detect a target nucleic acid.


Gen-Probe has been awarded US Patent No. 8,124,335, "Compositions and assays to detect influenza virus A and B nucleic acids."

Elizabeth Marlowe, Paul Darby, Damon Getman, Sylvia Norman, and Reinhold Pollner are named as inventors on the patent.

Discloses methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection. Also discloses target-specific nucleic acid sequences and kits comprising target-specific nucleic acid oligomers for amplifying influenza virus A or influenza virus B nucleic acid in vitro; and detecting amplified nucleic acid sequences.


Applied DNA Sciences has been awarded US Patent No. 8,124,333, "Methods for covalent linking of optical reporters."

Thomas Kwok, Ming-Hwa Liang, and Stephane Shu Kin So are named as inventors on the patent.

Describes a method to link a light-emitting reporter to biomolecules with nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle prior to which biomolecules are then covalently linked. The light reporter particle can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.

The Scan

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.

Computer Model Uses Genetics, Health Data to Predict Mental Disorders

A new model in JAMA Psychiatry finds combining genetic and health record data can predict a mental disorder diagnosis before one is made clinically.

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.