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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Nov 11, 2010

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Qiagen has been awarded US Patent No. 7,829,691, "Detection of nucleic acids by type-specific hybrid capture method."

James Anthony, Attila Lorincz, John Troy, and Yanglin Tan have been named as inventors on the patent.

Describes target-specific hybrid capture, a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences, the patent's abstract states. The method produces DNA-RNA hybrids, which can be detected by a variety of methods.


Eppendorf Array Technologies has been awarded US Patent No. 7,829,313, "Identification and quantification of a plurality of biological (micro)organisms or their components."

Isabelle Alexandre, Sylvian Margaine, Dieter Husar, Nathalie Zammatteo, Heinz Koehn, and Jose Remacle are named as inventors on the patent.

Discloses a system and method for conducting real-time PCR. The method involves immobilizing capture molecules of a specific design on a solid support, and contacting them with amplicons produced in one or more PCR cycles. Amplicon detection may take place during or between the PCR cycles while the solid support is in fluidic contact with the PCR solution. In an alternate embodiment, amplicon detection takes place when the solid support is not in fluidic contact with the PCR solution. The method is suitable for simultaneously detecting and quantifying closely homologous target molecules, the patent's abstract states.


New England Biolabs has been awarded US Patent No. 7,829,284, "Helicase-dependent amplification of nucleic acids."

Huimin Kong, Myriam Vincent, and Yan Xu are named as inventors on the patent.

Provides methods and a kit for selectively and exponentially amplifying nucleic acids and includes the use of a helicase preparation and a DNA polymerase such that the amplification can be performed isothermally.

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In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.