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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Jul 28, 2011

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Illumina has been awarded US Patent No. 7,985,565, "Method of nucleic acid amplification."

Pascal Mayer, Laurent Farinelli, and Eric Kawashima are named as inventors on the patent.

Describes a process by which a nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilized primer and the other primer can be extended. Both extended primers can then be separated from one another and can be used to provide further extended primers. The process can be repeated to provide amplified, immobilized nucleic acid molecules, which can be used for many different purposes, including sequencing, screening, diagnosis, in situ nucleic acid synthesis, monitoring gene expression, and nucleic acid fingerprinting, among other applications.


Harvard University has been awarded US Patent No. 7,985,546, "Genomic library construction."

George Church and Kun Zhang are named as inventors on the patent.

Provides compositions and methods for amplifying nucleic acid sequences and/or constructing a genomic library from a single cell.


Delta of Hørsholm, Denmark, has been awarded US Patent No. 7,985,540, "Method, chip, device, and system for extraction of biological materials."

Gert Jensen, Lars Thomsen, and Oene Veltman are named as inventors on the patent.

Relates to a method, chip, device, and system for extracting biological material form cells. The invention involves exposing the biological particles to an alternating electric field in a sample chamber and may also involve subsequent analysis of the biological material after the extraction.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.