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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Oct 14, 2010

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The University of California and the Hospital for Sick Children in Toronto have been awarded US Patent No. 7,811,986, "Genes from the 20Q13 amplicon and their uses."

Joe Gray, Colin Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, and Johanna Rommens are listed as inventors on the patent.

Relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods to identify chromosomal abnormalities associated with various diseases. The sequences can also be used in the treatment of diseases.


Fermentas (now part of Thermo Fisher) has been awarded US Patent No. 7,811,807, "Nucleic acid purification."

Rimantas Kvederas, Asta Siksniute, and Alyimantas Markauskas are listed as inventors on the patent.

Discloses a process for purifying plasmid DNA from a nucleic acid containing sample comprising plasmid DNA and contaminants. The process includes a contaminant-removal step comprising: (a) treating the sample to form a nucleic acid solution having a concentration of monovalent cations; (b) contacting the nucleic acid solution with an ultrafiltration membrane having a molecular weight exclusion limit of at least 30 kilodaltons under conditions in which substantially no gel layer forms and in which the concentration of monovalent cations is sufficiently high to allow sufficient time to remove substantially all RNA and form a retentate containing plasmid DNA; and (c) collecting the retentate.


Fujifilm has been awarded US Patent No. 7,811,758, "Method and apparatus of automatically isolating and purifying nucleic acid."

Toshihiro Mori and Yoshihiko Makino are listed as inventors on the patent.

Provides a method of automatically isolating and purifying nucleic acid from a nucleic acid-containing specimen. The method comprises injecting a liquid from at least one opening into a cartridge that contains at least two openings and includes a container having at least two openings and containing a nucleic acid-adsorbent solid phase. The liquid is passed through the nucleic acid-adsorbent solid phase by a generated pressure difference between the inside and outside of the container; and discharged from the other opening of the container to the outside of the container by a generated pressure difference. A pressure generated in the inside of the container is measured, and pressure change velocity and acceleration are calculated on the basis of the value of the measured pressure. Further, the timing of completion of discharge of the liquid from the container is determined by use of a temporal change pattern of at least one of the measured pressure, pressure change velocity, and pressure change acceleration.


Ibis Biosciences (now part of Abbott) has been awarded US Patent No. 7,811,753, "Methods for repairing degraded DNA."

Mark Eshoo is the sole inventor listed on the patent.

Provides methods and kits to repair degraded DNA, which may then be used as a template for efficient amplification by a number of different amplification reactions. The method relies upon a series of enzymatic activities provided by DNA repair enzymes.


Novartis Vaccine and Diagnostics has been awarded US Patent No. 7,807,813, "Identification of oligonucleotides for the capture, detection and quantitation of West Nile virus."

Venkatakrishna Shyamala is the sole inventor listed on the patent.

Discloses West Nile virus-capture oligonucleotides, primers, and probes derived from conserved regions of the West Nile virus genome. Also discloses nucleic acid-based assays using the capture oligonucleotides, primers, and probes.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.