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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Sep 22, 2010

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Samsung Electronics of Seoul, South Korea, has been awarded US Patent No. 7,799,557, "Polymerase chain reaction module and multiple PCR system using the same."

Kwang-wook Oh, Jin-tae Kim, Kak Namkoong, Chin-sung Park, and Yoon-kyoung Cho are named as inventors on the patent.

Provides a DNA PCR module and a multiple PCR system using the same. More particularly, the patent provides a DNA PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.


Human Genetic Signatures of Sydney, Australia, has been awarded US Patent No. 7,799,525, "Methods for genome amplification."

Douglas Millar is the sole inventor listed on the patent.

Provides a method for whole genome amplification comprising: (a) treating genomic DNA with a modifying agent which modifies cytosine bases but does not modify 5'-methyl-cytosine bases under conditions to form single-stranded modified DNA; (b) providing a population of random X-mers of exonuclease-resistant primers capable of binding to at least one strand of the modified DNA, wherein X is an integer 3 or greater; (c) providing polymerase capable of amplifying double stranded DNA, together with nucleotides and optionally any suitable buffers or diluents to the modified DNA; and (d) allowing the polymerase to amplify the modified DNA.


The Public Health Research Institute of the City of New York has been awarded US Patent No. 7,799,522, "Specific double-stranded probes for homogeneous detection of nucleic acid and their application methods."

Qingge Li, Jixuan Liang, and Guoyan Luan are named as inventors on the patent.

Describes double-stranded nucleic acid hybridization probes that comprise a longer strand perfectly complementary to a preselected target sequence in an assay and a shorter second strand complementary to the longer strand. The strands are labeled with interactive labels such as a fluorophore and a quencher. The probes may be used in real-time amplification assays to distinguish among alleles, according to the patent's abstract.


Chen & Chen of Framingham, Mass., has been awarded US Patent No. 7,799,521, "Thermal cycling."

Shuqi Chen, founder and CEO of biological testing company Iquum, is the sole inventor listed on the patent.

Describes a device for processing a biological sample. The device includes a processing unit having at least one opening to receive a sample vessel and a plurality of processing stations positioned along the opening. The processing stations each have a compression member adapted to compress the sample vessel within the opening and thereby move a substance within the sample vessel among the processing stations. An energy transfer element can be coupled to one or more of the processing stations for transferring thermal energy to the content at a processing station.

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