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IP Watch: Qiagen, Illumina, Canon, Others Win US Patents

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The Regents of the University of California have been awarded US Patent No. 8,778,608, "CA9 gene single nucleotide polymorphisms predict prognosis and treatment response of metastatic renal cell carcinoma."

Arie Belldegrun and Allan Pantuck are named as inventors.


Good Start Genetics has been awarded US Patent No. 8,778,609, "Methods for analyzing nucleic acids."

Mark Umbarger is named as the inventor.


Rubicon Genomics has been awarded US Patent No. 8,778,610, "Methods for preparing amplifiable DNA molecules."

Vladimir Makarov, Emmanuel Kamberov, and Brendan Tarrier are named as inventors.


Canon US Life Sciences has been awarded US Patent No. 8,778,637, "Method and apparatus for applying continuous flow and uniform temperature to generate thermal melting curves in a microfluidic device."

Ivor Knight and Deborah Boyles are named as inventors.


Lawrence Livermore National Security has been awarded US Patent No. 8,778,663, "Thermal cycler."

William Benett, John Andreski, John Dzenitis, Anthony Makarewicz, Dean Hadley, and Satinderpall Pannu are named as inventors.


Qiagen has been awarded US Patent No. 8,778,842, "Sample lysis and coating of reaction surface."

Ralf Himmelreich, Roland Fabis, Christoph Erbacher, Sabine Werner, and Bernd Springer are named as inventors.


Illumina has been awarded US Patent No. 8,778,848, "Patterned flow-cells useful for nucleic acid analysis."

Shengrong Lin, Yir-Shyuan Wu, Kevin Gunderson, and John Moon are named as inventors.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.