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IP Watch: LLNL, Fuso Pharma, Universidad de Cordoba, Columbia U, Hologic, Others Win US Patents

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Lawrence Livermore National Security has been awarded US Patent No. 8,354,514, "Multiplex detection of agricultural pathogens."

Thomas Siezak, Shea Gardner, Clinton Torres, Elizabeth Vitalis, and Raymond Lenhoff are named as inventors.

Describes kits and methods useful for detecting agricultural pathogens in a sample. Genomic sequence information from agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR-based, multiplexed Luminex assay and/or an array assay to successfully identify the presence or absence of pathogens in a sample.


Fuso Pharmaceutical Industries of Osaka, Japan, has been awarded US Patent No. 8,354,500, "Cytolethal distending toxins and detection of Campylobacter bacteria using the same as a target."

Shinji Yanasaki and Masahiro Asakura are named as inventors on the patent.

Describes cloning and determination of the sequences of the previously unknown CDT genes of Campylobacter coli and C. fetus. In addition, the patent discloses specific primers and primers common to the two species that were developed by comparing the CDTs of C. jejuni and C. fetus. These primers are applicable to multiplex PCR that simultaneously allows for the rapid and convenient determination of the presence of Campylobacter CDT and identification of species, and can also be used in PCR-RFLP-based typing.


Universidad de Cordoba in Spain has been awarded US Patent No. 8,354,273, "Isoforms of human somatostatin receptor type 5."

Mario Prado, Antonio Fuentes, Rafael Martinez, Socorro Navarro, Maria del Mar Malagon Poyato, Justo Fuentes, and Francisco Garcia-Navarro are named as inventors.

Discloses two human nucleic acids comprising sequences that code sst5B and sst5C, two novel isoforms of human somatostatin receptor type 5 produced by alternative adjustment and with possible uses in tumoral processes. Additionally, the invention discloses oligonucleotide pairs used for the differential detection of said isoforms by means of PCR in different tissues.


Columbia University has been awarded US Patent No. 8,354,227, "Binary deoxyribozome probes for nucleic acid analysis."

Dmitry Kolpaschchikov is named as the inventor.

Describes binary deoxyribozyme or ribozyme probes and methods that allow the detection of nucleic acids under mild physiologic conditions with extraordinary specificity and high sensitivity to single-nucleotide mismatches without PCR amplification.


Gen-Probe (Hologic) has been awarded US Patent No. 8,354,226, "Assay for detection of human parvovirus B19 nucleic acid."

Steven Brentano, Margarita Batranina-Kaminsky, Cynthia Hasselkus-Light, and Daniel Kolk are named as inventors.

Describes nucleic acid oligomers specific for human parvovirus B19 genomic DNA, and an assay for amplifying and detecting human parvovirus B19 nucleic acid in biological specimens. The patent also discloses compositions for detecting the presence of parvovirus B19 genomic DNA in human biological specimens.


US Patent No. 8,354,225, "Amplification of oligonucleotides containing non-standard nucleobases," has been issued to an unspecified party.

Steven Benner and Albert Sismour are named as inventors on the patent. Benner is a researcher at the Foundation of Applied Molecular Evolution and founder of startup company Firebird Biomolecular Sciences (PCR Insider, 12/22/2011).

Relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. Most specifically, the invention discloses and claims processes for amplifying nucleic acid analogs containing non-standard nucleobases using PCR, and enzymes that perform this amplification.

The Scan

Dropped Charges

The US Justice Department has dropped visa fraud charges against five Chinese researchers, according to the Wall Street Journal.

More Kids

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In PNAS this week: ancient rat genome analysis gives hints to human migrations, WDR77 gene mutations in thyroid cancer, and more.

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.