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IP Watch: Hologic, Qiagen, Rubicon, IDT, U of Utah, BioFire Diagnostics, Others Win US Patents


Greiner Bio-One, of Frickenhausen, Germany, has been awarded US Patent No. 8,399,652, "Primers and probes for detecting genital HPV genotypes."

Wolfgang Kranewitter, Christian Mittermayr, Florian Winner, and Thomas Iftner are named as inventors.

Relates to oligonucleotides suited as primers for amplifying DNA of genital human papilloma viruses; oligonucleotides suited for use as probes to typify genital HPV genotypes; methods for amplifying the DNA of genital HPV; methods for detecting and/or identifying genital HPV genotypes; nucleotide microarrays containing the oligonucleotides; kits and use of the oligonucleotides to amplify or typify genital HPV genotypes; diagnosis and/or early diagnosis of diseases; and producing agents for diagnosing diseases.

Gen-Probe (Hologic) has been awarded US Patent No. 8,399,222, "Compositions and methods for detecting small RNAs, and uses thereof."

Amara Siva and Mark Reynolds are named as inventors.

Provides compositions and methods for sensitive and specific detection of small RNA target nucleic acids, preferably miRNA target nucleic acids. The compositions and methods include using one or more of a first amplification oligomer that is preferably an extender primer, a target-capture oligomer that is preferably at least partially double-stranded, a promoter primer/provider, a reverse primer that is preferably a universal primer, and a detection probe. The compositions and methods are useful for diagnostics, prognostics, monitoring the effectiveness of treatment, and/or determining a treatment, according to the patent's abstract.

SABiosciences (Qiagen) has been awarded US Patent No. 8,399,221, "Methods for detection and quantitation of small RNAs."

Daniel Kim and Yexun Wang are named as inventors.

Describes improved methods that increase the specificity and sensitivity of the detection of small RNAs, including miRNAs, using oligonucleotide primers and nucleic acid amplification. More specifically, the patent describes reaction conditions that result in a preferential decrease in cDNA synthesis of RNAs other than the small RNA molecules targeted for detection during miRNA tailing and reverse transcription reactions. Using these reaction conditions achieves greater sensitivity and specificity of amplification of small RNAs including miRNAs.

Qiagen has also been awarded US Patent No. 8,399,191, "Forensic identification."

Rebecca Barber, Michael Barber, Peter Johnson, Sharon Gillbard, Marc Haywood, Carolyn Smith, Jennifer Arnold, Trudy Burke, Andrew Urquhart, and Peter Gill are named as inventors.

Provides allelic ladder mixtures and individual alleles suitable for use in such mixtures. The allelic ladder mixtures give improved identification and distinguishing capabilities particularly suitable in forensic investigations.

Rubicon Genomics has been awarded US Patent No. 8,399,199, "Use of stem-loop oligonucleotides in the preparation of nucleic acid molecules."

Vladimir Makarov, Emmanuel Kamberov, and Brendan Tarrier are named as inventors.

Concerns the preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and conditions. In particular, at least part of the inverted palindrome is removed during the preparation of the molecules to facilitate their amplification. Thus, in specific embodiments, the DNA molecules are suitable for amplification and are not hindered by the presence of the palindrome.

Integrated DNA Technologies has been awarded US Patent No. 8,399,197, "Methods for amplifying polymeric nucleic acids."

Mark Behlke, Joseph Walder, and Jeffrey Manthey are named as inventors.

Provides compositions and methods for amplifying nucleic acid polymer sequences in a high-complexity nucleic acid sample. The unique compositions of the invention include a primer set composed of a mixture of two types of primers for DNA synthesis. For extension in one direction, the primers all contain modifications that destroy their ability to serve as templates that can be copied by DNA polymerases. For extension in the opposite direction the set includes at least one primer that can serve as a template and be replicated by DNA polymerases throughout its length. The method can be carried out by mixing the nucleic acid polymer sequence of interest with the set of DNA synthesis primers in an amplification reaction mixture. The reaction mixture is then subjected to temperature cycling analogous to the temperature cycling in PCR reactions. At least one primer in the primer set hybridizes to the nucleic acid polymer. It is preferred that the non-replicable primer hybridizes to the nucleic acid polymer and is extended to produce a product that contains sequence from the nucleic acid polymer to which the replicable primer then hybridizes. If the nucleic acid polymer is double-stranded, both the replicable and nonreplicable primers will hybridize and be extended by DNA polymerase.

The University of Louisville Research Foundation has been awarded US Patent No. 8,399,195, "Detecting genetic abnormalities."

Aoy Mitchell and Michael Mitchell are named as inventors.

The patent is directed to compositions and methods for detecting genetic abnormalities. The invention encompasses methods and compositions for comparing alleles in a sample containing both maternal and fetal nucleic acids in order to identify genetic abnormalities.

The University of Utah Research Foundation and BioFire Diagnostics have been awarded US Patent No. 8,399,189, "Primers for melting analysis."

Carl Wittwer, Luming Zhou, and Mark Poritz are named as inventors.

Provides methods and kits for nucleic acid analysis. In an illustrative method a target nucleic acid is amplified using a first primer and a second primer. The first primer comprises a probe element specific for a locus of the target nucleic acid and a template-specific primer region, and the probe element is 5' of the template-specific primer region. This subsequently allows the probe element to hybridize to the locus to form a hairpin. By measuring fluorescence from a dsDNA-binding dye as the mixture is heated, wherein the dye is not covalently bound to the first primer, a melting curve for the probe element can be generated and its shape analyzed. Kits may include one or more of the first and second primers, the dsDNA-binding dye, a polymerase, and dNTPs.

Enzo Life Sciences has been awarded US Patent No. 8,394,949, "Multisignal labeling reagents, and processes and uses therefor."

Elazar Rabbani, Jannis Stavrianopoulos, and James Donegan are named as inventors.

Provides multisignal labeling reagents useful in a number of biochemical applications, including the manufacture of biomolecular probes and detection or amplification of analyte-specific moieties.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.