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IP Watch: Glaxo Group, Hitachi, City of Hope, Esoterix, Penn State, Others Win US Patents

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The Biological Research Center of the Hungarian Academy of Sciences and Glaxo Group Limited, a subsidiary of GlaxoSmithKline, have been jointly awarded US Patent No. 8,389,802, "Artificial chromosomes, uses thereof, and methods for preparing artificial chromosomes.

Gyula Hadlaczky and Aladar Szalay are named as inventors.

Provides methods for amplifying nucleic acids in cells. Also describes cells that contain the nucleic acids.


National Applied Research Laboratories of Taipei, Taiwan, has been awarded US Patent No. 8,389,273, "Polymerase chain reaction method, polymerase chain reaction droplet device, and polymerase chain reaction droplet device array."

Chih-Sheng Yu, Yi-Chiuem Hu, and Fan-Gang Tseng are named as inventors.

Discloses a PCR method, a PCR droplet device, and a PCR droplet device array. The method includes dropping a liquid on the heating coil disposed on the droplet device to form a droplet, then dropping a hydrophobic solution to prevent the droplet from evaporating. When an electric current or a voltage is supplied through at least one conducting wire to heat the heating coil, the inside of the droplet can generate buoyancy to drive the analyzer to move to the top of the inside of the droplet. Subsequently, the analyzer is moved to a periphery inside the droplet so as to form a thermal cycle. Therefore, the template is amplified by recycling the thermal cycle.


Hitachi has been awarded US Patent No. 8,389,246, "Method for nucleic acid quantitation."

Kiyomi Taniguchi and Hideki Kambara are named as inventors.

Describes an approach for DNA quantitative analysis that is intended to overcome the disadvantages of conventional formulations. A standard DNA sample is prepared by introducing a single-base substitution into target DNA, and a predetermined amount thereof is mixed with a target DNA sample. The target and standard DNAs are amplified using the same primers designed to amplify a region comprising the single-base substitution site. Nucleoside triphosphates ddATP, ddGTP, ddCTP, and ddTTP are sequentially added one by one to a hybridization product of a probe capable of binding to a site immediately before the single-base substitution site, in order to perform a complementary strand synthesis reaction. Luciferase reaction-induced luminescence derived from the formed pyrophosphoric acid is detected, and the target DNA is quantitated from the amount of the detected luminescence and the amount of the added standard DNA sample


City of Hope has been awarded US Patent No. 8,389,244, "Methods and kits for synthesis of siRNA expression cassettes."

John Rossi and Daniela Castanotto are named as inventors.

Describes amplification-based methods and kits for rapidly producing siRNA expression cassettes; and methods for expressing amplified siRNA expression cassettes in cells.


The country of Japan, as represented by the Director General of Japan's National Institute of Infectious Diseases>/b>, has been awarded US Patent No. 8,389,221, "Method of detecting H5 or H7 avian influenza virus."

Harumi Minekawa, Toshihiro Yonekawa, and Takato Odagiri are named as inventors.

The patent provides oligonucleotide primers that specifically hybridize to an arbitrary nucleotide sequence designed from the nucleotide sequence of hemagglutinin of an H5 or H7 avian influenza virus; a nucleic acid amplification method using the primers; a method for diagnosing infection with an H5 or H7 avian influenza virus by detecting nucleic acid amplification; and a kit for diagnosing influenza.


Esoterix Genetic Laboratories has been awarded US Patent No. 8,389,220, "Method for detecting a recombinant event."

Anthony Shuber is named as inventor.

Describes methods [for] isolating and amplifying chimeric nucleic acid molecules. The methods are useful for detecting chromosome translocation events associated with diseases or conditions, such as cancer.


The Penn State Research Foundation has been awarded US Patent No. 8,389,216, "Methods for nucleic acid manipulation."

Stephen Benkovic and Frank Salinas are named as inventors.

Describes a method for replicating and amplifying a target nucleic acid sequence. One aspect of the method involves forming a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high-fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species; and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein, and a clamp loader protein derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.

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