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IP Watch: Gen-Probe, GE, NEC, DKFZ, and Omega Bio-Tek Win US Patents

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Gen-Probe has been awarded US Patent No. 8,202,978, "Compositions for detecting group A streptococci."

Reinhold Pollner and Paul Darby are named as inventors on the patent.

Provides compositions, methods, and kits for detecting Group A streptococci. In particular, the patent describes oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group A streptococci nucleic acids.


GE has been awarded US Patent No. 8,202,972, "Isothermal DNA amplification."

John Nelson, Robert Duthie, Carl Fuller, Gregory Grossmann, and Anuradha Sekher are named as inventors on the patent.

Provides nucleic acid synthesis methods and agents that employ an endonuclease — for example, endonuclease V — to introduce a nick into a target DNA including one or more inosine; and that use a DNA polymerase to generate amplicons of the target DNA.


NEC has been awarded US Patent No. 8,202,722, "Temperature control method and system."

Minoru Asogawa, Hisashi Haiwara, and Tohru Hiramatsu are named as inventors on the patent.

Describes an apparatus and method for heating or cooling a sample contained in a vessel portion through a heat-transfer member held in contact with the vessel. The vessel has an elastic member that expands and contracts for injection and discharge of the sample, and is closed other than a port that connects to a channel connected to the vessel.

The vessel portion is contracted in a non-contacting state with the heat transfer member, and expands correspondingly to contact the heat-transfer member when a predetermined amount of sample is injected through an inflow channel into the vessel. The vessel portion is then heated or cooled through the heat-transfer member.

The technology is used for conducting a PCR, for example, according to the patent's claims.


The German Cancer Research Center (DKFZ) has been awarded US Patent No. 8,202,694, "Composition comprising an oligonucleotide mixture for improved detection of human papillomavirus genotypes."

Markus Schmitt, Tim Waterboer, and Michael Pawlita are named as inventors on the patent.

Relates to a composition comprising an oligonucleotide mixture; the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject; a method for diagnosing different HPV genotypes in a sample of a subject; and a kit for carrying out said method.


Omega Bio-Tek has been awarded US Patent No. 8,202,693, "Method of isolation of nucleic acids."

Qi Guo is named as inventor on the patent.

Describes a method of isolating nucleic acids from a biological sample of cells. The method combines solid phase cell nuclei isolation with solid phase nucleic acid isolation.

The Scan

Review of Approval Process

Stat News reports the Department for Health and Human Services' Office of the Inspector General is to investigate FDA's approval of Biogen's Alzheimer's disease drug.

Not Quite Right

A new analysis has found hundreds of studies with incorrect nucleotide sequences reported in their methods, according to Nature News.

CRISPR and mRNA Together

Time magazine reports on the use of mRNA to deliver CRISPR machinery.

Nature Papers Present Smartphone Platform for DNA Diagnosis of Malaria, Mouse Lines for Epigenomic Editing

In Nature this week: a low-cost tool to detect infectious diseases like malaria, and more.