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IP Watch: Gen-Probe, GE, NEC, DKFZ, and Omega Bio-Tek Win US Patents

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Gen-Probe has been awarded US Patent No. 8,202,978, "Compositions for detecting group A streptococci."

Reinhold Pollner and Paul Darby are named as inventors on the patent.

Provides compositions, methods, and kits for detecting Group A streptococci. In particular, the patent describes oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group A streptococci nucleic acids.


GE has been awarded US Patent No. 8,202,972, "Isothermal DNA amplification."

John Nelson, Robert Duthie, Carl Fuller, Gregory Grossmann, and Anuradha Sekher are named as inventors on the patent.

Provides nucleic acid synthesis methods and agents that employ an endonuclease — for example, endonuclease V — to introduce a nick into a target DNA including one or more inosine; and that use a DNA polymerase to generate amplicons of the target DNA.


NEC has been awarded US Patent No. 8,202,722, "Temperature control method and system."

Minoru Asogawa, Hisashi Haiwara, and Tohru Hiramatsu are named as inventors on the patent.

Describes an apparatus and method for heating or cooling a sample contained in a vessel portion through a heat-transfer member held in contact with the vessel. The vessel has an elastic member that expands and contracts for injection and discharge of the sample, and is closed other than a port that connects to a channel connected to the vessel.

The vessel portion is contracted in a non-contacting state with the heat transfer member, and expands correspondingly to contact the heat-transfer member when a predetermined amount of sample is injected through an inflow channel into the vessel. The vessel portion is then heated or cooled through the heat-transfer member.

The technology is used for conducting a PCR, for example, according to the patent's claims.


The German Cancer Research Center (DKFZ) has been awarded US Patent No. 8,202,694, "Composition comprising an oligonucleotide mixture for improved detection of human papillomavirus genotypes."

Markus Schmitt, Tim Waterboer, and Michael Pawlita are named as inventors on the patent.

Relates to a composition comprising an oligonucleotide mixture; the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject; a method for diagnosing different HPV genotypes in a sample of a subject; and a kit for carrying out said method.


Omega Bio-Tek has been awarded US Patent No. 8,202,693, "Method of isolation of nucleic acids."

Qi Guo is named as inventor on the patent.

Describes a method of isolating nucleic acids from a biological sample of cells. The method combines solid phase cell nuclei isolation with solid phase nucleic acid isolation.

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.