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IP Watch: Fluidigm, Fred Hutchinson CRC Win US Patents

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Fluidigm has been awarded US Patent No. 8,450,065, "Copy number variation determination, methods, and systems."

Ramesh Ramakrishnan is named as inventor.

Provides methods and systems, including amplification-based techniques, for determining copy number variation of a target polynucleotide in a genome of a subject. Methods can include pre-amplification of the sample followed by distribution of sample and a plurality of reaction volumes; quantitative detection of a target polynucleotide and a reference polynucleotide; and analysis so as to determine the relative copy number of the target polynucleotide sequence in the genome of the subject.

Fluidigm has also been awarded US Patent No. 8,450,063, "Determination of copy number differences by amplification."

Simant Dube, Alain Mir, Ramesh Ramakrishnan, Lesley Weaver, and Bernhard Zimmermann are named as inventors.

Provides methods for determining relative copy number difference for one or more target nucleic acid sequences between a test sample and a reference sample or reference value derived therefrom. The methods facilitate the detection of copy number differences less than 1.5-fold.


Fred Hutchinson Cancer Research Center has been awarded US Patent No. 8,450,059, "Quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis."

David Fredericks, Prasanna Khot, and Daisy Ko are named as inventors.

Quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis in a patient sample such as bronchoalveolar lavage fluid. The methods involve isolating a patient sample, optionally extracting DNA from the sample, carrying out a quantitative PCR reaction on the sample to generate an amplicon that includes a region of an Aspergillus spp. ribosomal RNA gene, and detecting the PCR amplicon. The disclosure also provides primers and primer sets for specifically detecting an Aspergillus spp. fungal pathogen in the presence of human ribosomal DNA.

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