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IP Watch: Arkray, Medarex, and Roche Win US Patents

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Arkray has been awarded US Patent No. 8,357,516, "Primer set for amplification of UGT1A1 gene, reagent for amplification of UGT1A1 gene containing the same, and the uses thereof."

Mitsuharu Hirai and Satoshi Majima are named as inventors.

Provides primer sets for amplifying target regions containing sites to be detected in the UGT1A1 gene by a gene amplification method. The primer sets can amplify the regions specifically. Three pairs of primer sets are used, including forward primers and reverse primers consisting of specific base sequences described in the patent claims. The use of these primer sets makes it possible to amplify three target regions including parts where three types of polymorphisms (UGT1A1*6, UGT1A1*27, and UGT1A1*28) of the UGT1A1 gene are generated, respectively, in the same reaction solution at the same time.


Medarex has been awarded US Patent No. 8,357,514, "Methods of gene amplification and expression."

Alahari Arunakumari, Xiao-Ping Dai, and Haile Ghebramarian are named as inventors.

Discloses methods relating to amplification and expression of a nucleic acid sequence encoding a polypeptide of interest in recombinant cells, and cell lines and polypeptides produced from such methods. The methods disclosed herein permit the amplification of cell lines that express a polypeptide of interest in a relatively short period of time through the use of a bioreactor.


Roche has been awarded US Patent No. 8,357,490, "Integrated instrument performing synthesis and amplification, and a system thereof."

Thomas Froehlich, Martin Guteknust, Dieter Heindl, Angelika Roseler, and Rudolf Seibl are named as inventors.

Describes an integrated instrument for oligonucleotide synthesis and PCR, and a system and method thereof. The integrated instrument is basically composed of two independent modules. The first module is a unit for chemical de novo synthesis of oligonucleotides such as oligonucleotide primers and/or oligonucleotide hybridization probes. The second module is a unit for performing an analytical PCR amplification in real time, i.e., qPCR. The two modules are operatively linked to each other in such a way that a user can load a nucleic sample to be analyzed into the integrated instrument and perform a PCR reaction by programming the instrument without a previous external synthesis of oligonucleotide amplification primers.

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