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IP Watch: Abbott, KU-Leuven R&D, Wayne State U, Epigenomics, US DHHS, and Penn State Win US Patents


Ibis Biosciences (Abbott) has been awarded US Patent No. 8,242,254, "Compositions for use in identification of bacteria."

Rangarajan Sampath, Thomas Hall, David Ecker, and Lawrence Blyn are named as inventors on the patent.

Provides compositions, kits, and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis. More specifically, the patent provides oligonucleotide primers and compositions, and kits containing the oligonucleotide primers, which define bacterial bioagent-identifying amplicons and, upon amplification, produce corresponding amplification products whose molecular masses provide the means to identify bacteria, for example, at and below the species taxonomic level.

KU Leuven Research and Development of Belgium has been awarded US Patent No. 8,242,087, "Phosphate-modified nucleosides useful as substrates for polymerases and as antiviral agents."

Olga Adelfinskaya and Piet Herdewijn are named as inventors on the patent.

Relates to novel phosphate-modified nucleosides, and methods for producing them, useful for the prevention or treatment of a viral infection in a mammal, and for preparing oligonucleotides by DNA/RNA polymerase-dependent amplification, e.g. PCR.

Wayne State University has been awarded US Patent No. 8,241,874, "Rolling circle amplification."

Maik Huttemann is named as inventor on the patent.

Provides a method to detect a messenger RNA sequence. The method includes annealing a first probe and a second probe to at least a portion of the mRNA, wherein the first and second probes do not comprise the same nucleotide sequence, and wherein each probe sequence is complementary to at least a portion of the mRNA and the second probe is a T-shaped probe having (1) a probe sequence complementary to at least a portion of the mRNA sequence and (2) a rolling circle amplification primer that is linked to an internal reactive group of the probe sequence of the second probe so as to provide physical separation of probe ligation and rolling circle amplification. The probe-connected rolling circle primer thus comprises a circle recognition sequence.

Epigenomics has been awarded US Patent No. 8,241,855, "Method for detecting cytosine methylations."

Kurt Berlin is named as inventors on the patent.

Describes a method for detecting 5-methylcytosine in genomic DNA samples. First, genomic DNA from a DNA sample is chemically converted with a reagent, whereby 5-methylcytosine and cytosine react differently. Then the pretreated DNA is amplified with the use of a polymerase with primers of different sequence. In the next step, the amplified genomic DNA is hybridized to an oligonucleotide array and PCR products are obtained. The PCR products must be provided with a label, or, alternatively, can be extended in a primer extension reaction, wherein the extension products are also provided with a label. In the last step, the extended oligonucleotides are investigated for the presence of the label.

The US Centers for Disease Control and Prevention of the Department of Health and Human Services has been awarded US Patent No. 8,241,853, "Primers and probes for detection and discrimination of types and subtypes of influenza viruses."

Stephen Lindstrom, Alexander Klimov, Nancy Cox, and Lamorris Loftin are named as inventors on the patent.

Describes methods of detecting influenza, including differentiating between type and subtype, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus is screened for the presence or absence of that nucleic acid, which in turn indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza-specific probe, influenza type-specific probe, and/or subtype-specific probe and an influenza nucleic acid. The patent also discloses probes and primers for the detection, typing and/or subtyping of influenza virus; and kits and arrays that contain the disclosed probes and/or primers.

The Penn State Research Foundation has been awarded US Patent No. 8,241,851, "Methods for nucleic acid manipulation."

Stephen Benkovic and Frank Salinas are named as inventors on the patent.

Describes a method for replicating and amplifying a target nucleic acid sequence. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high-fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein, and a clamp loader protein derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.

The Scan

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Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.