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IP Update: Recent Patents Related to PCR, Sample Prep, and Nucleic Acid Amplification: Mar 9, 2010

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US Patent No. 7,674,582. Methods for amplification monitoring and gene expression profiling involving real-time amplification reaction sampling.

Inventor: Vladimir Slepnev

Assignee: PrimeraDx

Relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest, particularly in real time. The patent provides methods for monitoring the amplification of one sequence or two or more sequences from a single sample, as well as methods for monitoring the amplification of one or more sequences from two or more samples. The monitoring methods permit improved determination of the abundance of one or more target nucleic acids, especially target RNA species, in one or more original samples.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.