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IP Update: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Aug 17, 2010

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Qiagen has been awarded US Patent No. 7,776,616, "Apparatuses and methods for isolating nucleic acid."

Ellen Heath and Ruth Shuman are named as inventors on the patent.

Relates to an apparatus and method for purifying and isolating nucleic acid. The system uses one or more automated stations to perform steps of the method, including loading a sample onto a solid support in a processing container, purifying the sample, and isolating nucleic acid from the sample. A pump or vacuum may be used in the apparatus for supplying fluids to the sample. A pump, vacuum, or centrifuge may be used to separate impurities from the sample or to separate nucleic acid from the solid support. The patent also discloses exemplary solid supports and sample processing containers.


Biotium and AlleLogic have been awarded US Patent No. 7,776,567, "Dimeric and trimeric nucleic acid dyes, and associated systems and methods."

Fei Mao, Wai-Yee Leung, and Xing Xin are named as inventors on the patent.

Relates to dimeric and trimeric nucleic acid dyes, and associated systems and methods. Such dyes may form a hairpin-like structure that enables them to stain nucleic acids via a release-on-demand mechanism, for example. Such dyes may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. The dyes may be useful in a variety of applications, such as in DNA quantitation in real-time PCR.


Wallac Oy (now PerkinElmer) has been awarded US Patent No. 7,776,530, "Integrated nucleic acid analysis."

Pia Ollikka and Alice Ylikoski are named as inventors on the patent.

Relates to an integrated method of nucleic acid analysis, and more particularly to a simplified sample pre-treatment, which renders the method more easily automated, where the sample is provided on or applied onto a solid matrix and the subsequent amplification and detection steps are performed in one single, sealed reaction vial without removing the matrix.

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