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IP Update: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Jul 22, 2010

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Elitech Holding of the Netherlands has been awarded US Patent No. 7,759,126, "Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for amplification (or PCR) analysis."

Sergey Lokhov and Eugene Lukhtanov are named as inventors on the patent.

Covers minor groove binder-oligonucleotide probes and methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form, exhibits very low background signal.


Roche Diagnostics has been awarded US Patent No. 7,759,107, "Thermostable nucleic acid polymerase from Thermococcus gorgonarius."

Waltraud Ankenbauer, Vitaly Svetlichny, Elizaveta Bonch-Osmolovskaya, Christine Ebenbichler, Bernhard Angerer, Gudrun Schmitz-Agheguian, and Frank Laue are listed as inventors on the patent.

The patent covers a purified thermostable enzyme derived from the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant; retains approximately 90 percent of its activity after incubation for two hours at 95°C in the presence of stabilizing agents; and possesses 3'-to-5' proofreading exonuclease activity. Thermostable DNA polymerases are useful in many recombinant DNA techniques, especially nucleic acid amplification by PCR, the patent's abstract states.


Researchers affiliated with the University of Saskatchewan and the National Research Council Canada Plant Biotechnology Institute have been awarded US Patent No. 7,759,064, "Development of PCR primers and primer mixtures for amplification of cnp60 target sequences."

Janet Hill, Jennifer Town, and Sean Hemmingsen are the inventors listed on the patent.

According to the patent's abstract, the researchers have developed the primer pair H1511 and H1261 as a replacement for primer pair H279/H280 for specific amplification of cpn60 universal target sequences in genomic DNA or in complex DNA mixtures, including those with high G and C content.


Third Wave Technologies (now Hologic) has been awarded US Patent No. 7,759,062, "T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low-level target nucleic acid detection."

Hatim Allawi, Vecheslav Elagin, Victor Lyamichev, Kwok Wu, Walter Iszczyszyn, Chris Fleming, LuAnne Chehak, and Scott Law are named as inventors on the patent.

The patent relates to systems, methods, and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The invention also relates to T-structure invasive cleavage assays, as well as T-structure-related, target-dependent non-target amplification methods and compositions. The invention further relates to methods, compositions, devices, and systems for consistent nucleic acid dispensing onto surfaces.


UT-Battelle has been awarded US Patent No. 7,759,057, "Method for analyzing microbial communities."

Jizhong Zhou and Liyou Wu are named as inventors on the patent.

The patent provides a method for quantitatively analyzing microbial genes, species, or strains in a sample that contains at least two species or strains of microorganisms. The method involves using an isothermal DNA polymerase to randomly and representatively amplify genomic DNA of the microorganisms in the sample; hybridizing the resultant polynucleotide amplification product to a polynucleotide microarray that can differentiate different genes, species, or strains of microorganisms of interest; and measuring hybridization signals on the microarray to quantify the genes, species, or strains of interest.

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