A team from the University of Potsdam in Germany has combined wild-type blocking PCR using locked nucleic acids with high-resolution melting analysis to detect DNA mutations of unknown type and position in a background of up to 10,000-fold wild-type DNA.

The researchers also used the method, dubbed WTB-HRM, to enrich and detect such known and unknown mutations in the cancer-related adenomatous polyposis coli, or APC, gene in tissue and stool samples of colorectal cancer patients.

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