German Group Develops New PCR Method to Detect Chromosomal Translocations at DNA Level | GenomeWeb

NEW YORK (GenomeWeb) — Researchers from three German institutions have developed a PCR-based method to sensitively detect recurrent leukemia-associated chromosomal translocations at the DNA level without prior knowledge of specific breakpoints.

The method, called genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), has advantages over PCR-based methods that use RNA/cDNA as a template and over well-established DNA-based methods such as long-range PCR, according to the researchers.

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