Skip to main content
Premium Trial:

Request an Annual Quote

Dx Focus: Luminex Gets FDA OK, CE Mark for xTAG CYP2C19 Kit


Luminex said this week that it has received US Food and Drug Administration clearance for the xTAG CYP2C19 kit, a comprehensive genotyping assay intended to help physicians determine patient treatment plans based on certain genetic variants of the P450 2C19 gene. The kit also received CE marking, making it available commercially in Europe.

Luminex's assay analyzes a patient's CYP2C19 genotype from genomic DNA extracted from EDTA or citrate anticoagulated whole blood samples. The assay is run on the Luminex 100/200 or MagPix instruments.

CYP2C19 is a clinically important gene that encodes a phase-one drug-metabolizing enzyme that is responsible for metabolizing a variety of prodrugs and drugs used to treat a number of conditions such as ulcers, seizures, malaria, and anxiety. It is also important in metabolizing drugs such as beta-blockers, anti-clotting agents, and some antidepressants.

In July, Luminex received FDA clearance for a new version of the xTAG CYP2D6 kit, which analyzes a patient's CYP2D6 genotype in order to aid physicians in determining therapeutic strategy for drugs metabolized by the P450 2D6 gene product. That assay also runs on the Luminex 100/200 instrument (PCR Insider, 7/18/2013).

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.