Skip to main content
Premium Trial:

Request an Annual Quote

Dx Focus: Asuragen's Xpansion Interpreter and GeneNews' SentinelGx Services

Premium

Asuragen last week launched Xpansion Interpreter through the Asuragen Clinical Services Laboratory, a CAP-Accredited CLIA laboratory.

According to Asuragen, Xpansion Interpreter is the first clinically available service for definitively determining the number and location of AGG interruptions associated with expansion of the Fragile X gene, and thus enables a better understanding of an individual's risk of having a child with Fragile X syndrome.

Fragile X syndrome results from an increased number of CGG repeats within a region of the Fragile X gene on the X chromosome. AGG interruptions within the CGG repeats have long been suggested to stabilize alleles to protect against expansion which leads to Fragile X. Yet, to date, genetic counselors have only been able to rely on the total number of CGG repeats to assess the risk of expansion, Asuragen said.

To address this, the company developed improved molecular technology that allows high-resolution analysis of AGG interruptions.

Asuragen said that the launch of Xpansion Interpreter builds upon AmplideX, the company's current CGG repeat-primed PCR research reagents. "With the ability to clinically determine the number and location of AGG interruptions, the long-time problem of determining the stability of certain Fragile X alleles becomes more clear, creating opportunities to improve patient care," Asuragen CEO Matt Winkler said in a statement.


GeneNews this week announced the launch of SentinelGx, a suite of pharmacogneomic and companion diagnostic BloodRNA services for drug development and personalized health management applications.

The SentinelGx services provide complete whole blood transcriptome analysis for RNA expression profiling of inflammatory pathways, immune system response, and cell signaling based on the company's Sentinel Principle technology.

A catalog of more than 2,200 TaqMan BloodRNA profiles is now available, including pathway-specific, disease-specific, and drug-specific gene signature panels clinically proven to express in whole blood, the company said. The disease-specific panels include gene signatures for numerous types of cancer and autoimmune, cardiovascular, infectious, and neurological diseases.

SentinelGx also features a wide menu of core laboratory services including RNA isolation, RNA quality control, bio-banking, real-time qPCR gene expression validation with TaqMan, and SYBR Green chemistries; and a full range of Affymetrix gene expression profiling services including 3' IVT, whole-transcript and SNP expression analysis.

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.