Classic Samples, New Analysis

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Formalin-fixed, paraffin-embedded tissue is routinely used for histopathological diagnosis, and by some accounts FFPE tissue remains the best tissue for microscopic examination in a clinical environment. However, FFPE tissue has had its issues — such as cross-linking of proteins and yield — that make its use in 'omics-related research and non-clinical settings challenging. It also contains RNA that can be fragmented during fixation and storage, making FFPE unsuitable for certain types of analysis.

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