NEW YORK (GenomeWeb) — Using PCR-based methods to detect mutations in the BCR-ABL1 kinase domain of chronic myeloid leukemia patients has been established as a critical tool for monitoring CML patient response to tyrosine kinase inhibitor therapy.

However, according to recent studies from Australian researchers, when PCR assays reveal the presence of a specific kind of mutation — so-called compound mutations, where more than one mutation occurs within the same BCR-ABL1 molecule — it may in fact be an artifact caused by PCR-mediated recombination.

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