Skip to main content
Premium Trial:

Request an Annual Quote

Transgenomic, Dana-Farber Expand ICE COLD-PCR License

NEW YORK (GenomeWeb) — Transgenomic said today that it has signed a licensing deal with the Dana-Farber Cancer Institute for exclusive worldwide rights to develop and commercialize multiplexed versions of its ICE COLD-PCR technology.

The new license covers all fields and applications of the multiplexed technology, enabling the simultaneous detection of multiple DNA mutations from a single liquid sample such as blood or urine, Transgenomic said.

The deal also expands on an existing license between Transgenomic and Dana-Farber for ICE COLD-PCR, which stands for "improved and complete enrichment-coamplification at lower denaturation temperature PCR" and was developed in the laboratory of Dana-Farber researcher Mike Makrigiorgos.

In 2009, Omaha, Neb.-based Transgenomic signed an exclusive licensing agreement with Dana-Farber to use COLD-PCR combined with Sanger sequencing and for mitochondrial DNA analysis. They followed that agreement in 2011 with an expanded license to include ICE COLD-PCR and the analysis of COLD-PCR products by pyrosequencing.

ICE COLD-PCR selectively focuses on only the mutated DNA in tumors that is useful for cancer diagnosis, monitoring, and treatment. It detects mutated DNA at 100- to 400-fold greater sensitivity than conventional approaches and enables identification of all tumor mutations, known and unknown, the company said.

"Multiplexing makes our ICE COLD-PCR technology far more efficient and allows us to assemble targeted panels of relevant mutations that can be simultaneously analyzed from a single sample," Transgenomic CEO Paul Kinnon said in a statement. "This should greatly increase its availability for routine use in cancer therapy, as well as for our biopharmaceutical customers who plan to use [multiplexed] ICE COLD-PCR to develop new cancer treatments and companion diagnostics."

The Scan

Support for Moderna Booster

An FDA advisory committee supports authorizing a booster for Moderna's SARS-CoV-2 vaccine, CNN reports.

Testing at UK Lab Suspended

SARS-CoV-2 testing at a UK lab has been suspended following a number of false negative results.

J&J CSO to Step Down

The Wall Street Journal reports that Paul Stoffels will be stepping down as chief scientific officer at Johnson & Johnson by the end of the year.

Science Papers Present Proteo-Genomic Map of Human Health, Brain Tumor Target, Tool to Infer CNVs

In Science this week: gene-protein-disease map, epigenomic and transcriptomic approach highlights potential therapeutic target for gliomas, and more