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Product Watch: Jun 2, 2011


Thermo Fisher Scientific this week launched the KingFisher Duo nucleic acid purification system.

The low- to medium-throughput system includes the KingFisher magnetic particle processor instrument, optimized DNA/RNA isolation kits, plastic consumables, and the Thermo Scientific BindIt software.

The system is designed to provide a flexible, fully-automated workflow, and has a compact footprint, making it ideal for space-restricted laboratories.

It can process a variety of sample types in volumes up to 5 mL; and can be modified for use in proteomics and cell isolation, the company said.

Singapore's Esco has launched the Spectrum 96 real-time thermal cycler.

The instrument features an 8-channel and six-color optical configuration designed to provide access to a broader range of fluorophores; and its custom Peltier heating element optimizes thermal cycling in 96 wells with 0.2 mL tubes, the company said.

Also, the Spectrum 96 features a bottom detection system for improved sensitivity; a highly sensitive PMT detector; and is compatible with multiple generic consumables and reagents, the company said.

Qiagen has launched the qBiomarker somatic mutation PCR array system, designed for rapid and accurate mutation profiling in basic research and drug development.

The assays consist of collections of pathway- or cancer-specific assays in 96- or 384-well plate formats with a number of cancer types and pathways, such as EGFR and ErbB2.

Laboratory experiments have shown that the PCR arrays provide a sensitivity of as low as 1 to 2 percent mutant DNA in a background of wild-type DNA, Qiagen said. Experiments require approximately two hours from sample to result, and comprise the steps of DNA extraction from a sample, amplification (if necessary), and PCR array cycling and analysis using any block-based real-time cycler, the company said.

Exiqon has launched an additional qPCR array for quantifying 749 mouse and rat microRNAs.

The new panel complements an earlier array sold by Exiqon, and contains primer sets for the most important mouse and rat microRNAs not available on the company's previous chip. According to the firm's website, it is priced at €721 ($1,037).

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.