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Product Watch: Jul 27, 2010


Seegene this week introduced the SeePrep and SeeCycler, clinical instruments optimized for the company's multiplex real-time PCR technology based on real amplicon detection technology.

SeePrep automates magnetic bead nucleic acid extraction. According to the company, the platform is suited to extracting nucleic acid from samples that are very difficult to extract using other methods.

SeeCycler uses patented block dissipation technology for accurate and fast heating and cooling rates, which improves DNA amplification efficiency and results in faster reaction times. The instrument has a 96-well capacity and uses six channels, which allows five separate analyses from one sample, the company said.

Seegene said that it can now provide a complete molecular diagnostic workflow including nucleic acid extraction, amplification, real-time detection, and analysis.

Bioo Scientific has launched the ExoMir kit for fractionation and RNA extraction from exosomes and other microparticles in cell-free fluids, the company said this week.

Exosomes are membrane-covered microparticles shed by cells into bodily fluids and shed into media used to culture eukaryotic cells. Traditional methods to recover exosomes require ultracentrifugation of samples for several hours or more to pellet the particles.

The ExoMir kit uses an alternative approach in which samples of about 10 mL to 30 mL are passed over syringe filters to capture exosomes and larger membrane-bound particles. The filters are then flushed with BiooPure-MP, an RNA extraction reagent, to lyse the captured particles and release their contents. Recovery of the low-mass amounts of RNA from the lysates is maximized by using an inert co-precipitant included in the kit, Bioo said.

ExoMir can be used to process blood serum, cerebrospinal fluid, and eukaryotic cell culture media.

BioServe this week announced a line of new PCR-based tests for detecting commercialized genetically modified organisms to a 0.1 percent limit of detection.

In addition, Beltsville, Md.-based BioServe said that its laboratories in India have received accreditation from the National Board of Testing and Calibration of Laboratories for detecting genetically modified materials in raw and processed foods.

Chemagen this week launched the Chemagic total RNA kit for isolating total RNA from stabilized blood.

The Chemagic kit is designed for the automated isolation of total RNA from 2.5 ml of blood collected in PAXgene RNA tubes with the Chemagic Magnetic Separation Module I, which can process up to 24 blood samples in parallel.

Typical yields are seven to 16 µg of total RNA, Chemagen said. The company also offers other kits for isolating different types of RNA, such as viral RNA and messenger RNA, and plans to launch kit for extracting RNA from cells and tissue.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.